General Method for the Synthesis of 1,4-Disubstituted 5-Halo-1,2,3-triazoles

A general method for the synthesis of 1,4-disubstituted 5-halo-1,2,3-triazoles has been developed. The one-pot two-step process consists of a CuAAC reaction of a copper(I) acetylide with an organic azide catalyzed by (aNHC)CuCl, followed by halogenation with N-chlorosuccinimide, N-bromosuccinimide, or I2. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Authors
Gribanov P.S. 1 , Topchiy M.A. 1 , Karsakova I.V. 2 , Chesnokov G.A. 2 , Smirnov A.Y. 1 , Minaeva L.I. 3 , Asachenko A.F. 1, 3 , Nechaev M.S. 1, 2
Journal
European Journal of Organic Chemistry
Issue number
35
Language
English
Pages
5225-5230
State
Published
Link
External link
DOI
10.1002/EJOC.201700925
Volume
2017
Year
2017
Organizations
  • 1 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Lenynsky Prospect 29, Moscow, 119991, Russian Federation
  • 2 M. V. Lomonosov Moscow State University, Leninskie Gory 1 (3), Moscow, 119991, Russian Federation
  • 3 Peoples' Friendship University of Russia, Miklukho-Maklay St., 6, Moscow, 117198, Russian Federation
Keywords
Alkynes; Azides; Click chemistry; Copper; Halogenation; Triazoles
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