Cytoprotector Trimetazidine in Complex Therapy of Severe Heart Failure after Myocardial Infarction

Aim. Evaluation of clinical efficacy of trimetazidine in patients with heart failure after myocardial infarction. Material. 130 patients (97 men and 33 women) aged 37-76 years with NYHA class III-IV heart failure after myocardial infarction divided into 2 groups: (1) standard therapy (ACE inhibitor, diuretic and glycoside), (2) standard therapy + trimetazidine. Duration of treatment - 12 months. Methods. Left ventricular function was assessed by echocardiography before and after 6 and 12 months of therapy. Results. 27 patients dropped out from the study due to different reasons. There were 10 deaths (13%) in group 1 and 6 deaths (11,3%) in group 2. Significant lowering of NYHA class was observed in both groups: from 3,31±0,05 to 2,38±0,10 (p<0,001) in group 1 and from 3,32±0,07 to 2,15±0,09 (p<0,001) in group 2. This was associated with improvement of left ventricular systolic function evidenced by significantly decreased end-systolic and end-diastolic volumes, increased cardiac output, ejection fraction, and percentage of fractional shortening. By the end of therapy ejection fraction and percentage of fractional shortening were higher in trimetazidine treated patients. Positive changes of left ventricular diastolic function (reduction of Ve/Va ratio at the account of both decreased early and increased atrial velocities) also occurred.

Authors
Terestchenko S.N.1 , Akimova O.S.1 , Demidova I.V.1 , Borisova N.E.1 , Moiseev V.S. 1
Journal
Publisher
KlinMed Consulting
Number of issue
9
Language
Russian
Pages
48-52
Status
Published
Volume
39
Year
1999
Organizations
  • 1 Russia Univ. of Friendship People, Vavilova, 61, 117292 Moscow, Russian Federation
Keywords
Heart failure, treatment; Left ventricular function; Trimetazidine
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/514/