A concise approach toward tetrazolyl-substituted benzazocines via a novel isocyanide-based multicomponent reaction

The synthesis of pharmacologically relevant isoquinoline-tetrazoles and benzazocine-tetrazoles via sequential azido-Ugi and alkyne-induced ring-expansion reactions starting from cotarnine chloride are reported. A one-pot, multicomponent reaction protocol toward the ring-expanded product is also described. © Georg Thieme Verlag Stuttgart New York.

Authors
Borisov R.S. 1 , Voskressensky L.G. 2 , Polyakov A.I.3 , Borisova T.N. 2 , Varlamov A.V. 2
Journal
Synlett
Number of issue
7
Language
English
Pages
955-958
Status
Published
Link
External link
DOI
10.1055/s-0033-1340861
Number
4585
Volume
25
Year
2014
Organizations
  • 1 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Science, 29, Leninsky Avenue, Moscow 119991, Russian Federation
  • 2 Peoples Friendship University of Russia 6, Miklukho-Maklaia Street, Moscow 117198, Russian Federation
  • 3 N. N. Blohin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russian Federation
Keywords
alkaloids; alkynes; domino reaction; multicomponent reaction; ring expansion
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/5055/
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TRANSFORMATION OF 4-SUBSTITUTED TETRAHYDRO-PYRROLOBENZODIAZEPINES IN A THREE-COMPONENT REACTION WITH METHYL PROPIOLATE AND INDOLE

Article
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Chemistry of Heterocyclic Compounds. Латвийский институт органического синтеза Латвийской академии наук / Springer New York Consultants Bureau. Vol. 49. 2014. P. 1785-1794