Oxidative stress in the alcoholic liver disease

Parameters reflecting oxidative stress (OS) have been studied in 37 patients with alcoholic liver disease (ALD) during admission to the hospital and 2 weeks after the beginning of therapy. The patients were divided into 3 groups: alcoholic hepatitis (AH), alcoholic cirrhosis with hepatic insufficiency (the group C by the Child-Paquet scale) and terminal stage patients (subsequently died). All patients were characterized by a significant increase in plasma products of lipid peroxidation (conjugated diene and malondialdehyde) and a decrease of the ceruloplasmin level. The coefficient C OS significantly exceeded normal values both on admission and after the 2-week course of traditional therapy. This suggests an important role of the OS with ALD. © 2014 Pleiades Publishing, Ltd.

Authors
Panchenko L.F.1 , Davydov B.V.2 , Terebilina N.N. 2 , Baronets V.Y.2 , Zhuravleva A.S. 3
Editors
-
Publisher
-
Number of issue
1
Language
English
Pages
73-76
Status
Published
Department
-
Number
-
Volume
8
Year
2014
Organizations
  • 1 Institute of General Pathology, Pathophysiology of Russian Academy of Medical Sciences, Moscow, Russian Federation
  • 2 National Scientific Center of Drug Addiction, M. Mogiltsevskii per. 3, Moscow 119002, Russian Federation
  • 3 Russian University of People's Friendship, Moscow, Russian Federation
Keywords
alcoholic liver disease; antioxidant system; lipid peroxidation; oxidative stress; reactive oxygen species
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/5031/