The influence of chemical polyamines analogs, decarboxylated ornithine and s-(adenosyl)-methionine on the polyamine synthesis velocity in test-systems from tissues with high proliferation

The aliphatic (amino)- and (oxy)-derivatives of polyamines effect on the rate of polyamines (Putrescine, Spermidine and Spermine) synthesis in cell-free test-systems from rat's regenerating liver and Hepatoma tissues was examined. The common known inhibitors of polyamines synthesis were also used for the analysis. The research data confirm that cell-free model systems function adequately to applied tests. The effectiveness of anti-proliferate action of chemical compounds was valued by the inhibition degree of Putrescine and polyamines synthesis. In addition, the coefficient of ratio Spermidine (moles)/Spermine (moles) and the value of total Polyamines pool after 1 h of test-systems incubation with chemical compound were calculated. From the tested compounds 1-aminooxy-3-aminopropan (I), S-(5'-desoxyadenosile)-S-methyl-β-thioethyl-hydroxylamine (IV) and ethylenediamine (V) did satisfied the requirements to a considerable degree.

Publisher
Research Journal of Pharmaceutical, Biological and Chemical Sciences
Number of issue
6
Language
English
Pages
1481-1485
Status
Published
Volume
5
Year
2014
Organizations
  • 1 Russian Peoples' Friendship University, Miklukho-Maklaya str., 8, Moscow, 117198, Russian Federation
Keywords
Difluoromethylornithine; Ornithine decarboxylase; Oxidative deamination; Polyamines; Putrescine; Spermidine; Spermine
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/4928/
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