Clinical symptoms of acute coronary insufficiency correlate with GP-IIIa genotype of integrin β-subunit

Studies of the clinical course of acute coronary insufficiency (progressive angina and myocardial infarction) in patients carrying a mutant allele of the Pl-A(II) gene encoding integrin GPIIIa β-subunit revealed significant differences in the incidence of some clinical signs in comparison with patients homozygous for the normal Pl-A(I) allele.

Authors
Maksimenko L.V. 1 , Moiseeva T.Yu. 2 , Tugarinova G.V. 3 , Karpova E.V. 1 , Frolov V.A. 2 , Itkes A.V. 1
Journal
Бюллетень экспериментальной биологии и медицины\r\nКлеточные технологии в биологии и медицине (Bulletin of Experimental Biology and Medicine)
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Issue number
6
Language
English
Pages
578-580
State
Published
Link
External link
DOI
10.1007/BF02434882
Volume
129
Year
2000
Organizations
  • 1 Department of Biology and General Genetics, Russian University of People Friendship, Moscow, Russian Federation
  • 2 Department of Pathophysiology, Russian University of People Friendship, Moscow, Russian Federation
  • 3 Municipal Clinical Hospital 36, Moscow, Russian Federation
Keywords
Acute coronary insufficiency; GP-IIIa; Integrin
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