The effect of alcohol consumption on maternal and cord blood electrolyte and trace element levels

Background. Earlier studies demonstrated that alcoholism significantly alters electrolyte and trace element homeostasis. However, the existing data on the interplay between maternal alcohol consumption and fetal trace element status are contradictory. Therefore, the primary objective of the present study was to assess the influence of alcohol consumption on maternal and cord blood trace elements. Material and methods. A total of 30 pregnant women (15 women consuming alcohol and 15 controls) were examined. Assessment of electrolyte and trace elements concentration in maternal (1 and 3 trimesters) and umbilical cord blood was performed using inductively-coupled plasma mass spectrometry. Results. In the first trimester of pregnancy alcohol consumption is associated with increased whole blood Ca and Na levels. In the third trimester of pregnancy, women consuming alcohol are characterized by significantly increased Co levels. Conversely, the level of Co and Mn in the cord blood of offspring maternally exposed to ethanol is decreased. A significant correlation between first trimester blood and cord blood concentrations of K was revealed both in control women and those consuming alcohol. In the third trimester of pregnancy in the control women, a significant correlation with cord blood was detected for Fe, Mg, P, and Pb. Oppositely, in the third trimester in women consuming alcohol we detected a close association between maternal whole blood and cord blood levels for Ca, Cd, and Pb. Conclusion. The data obtained demonstrate that maternal alcohol consumption results in fetal Co and Mn deficiency. © Wydawnictwo Uniwersytetu Przyrodniczego w Poznaniu.

Authors
Skalny A.V. 1, 2, 3, 4 , Berezkina E.S. 1, 4 , Kiyaeva E.V.3 , Alidzhanova I.E.3 , Grabeklis A.R.1 , Tinkov A.A. 1, 3, 4, 5
Publisher
Wydawnictwo Uniwersytetu Przyrodniczego w Poznaniu
Number of issue
4
Language
English
Pages
439-445
Status
Published
Volume
15
Year
2016
Organizations
  • 1 P.G. Demidov Yaroslavl State University, Sovetskaya 14, Yaroslavl, 150000, Russian Federation
  • 2 All-Russian Research Institute of Medicinal and Aromatic Plants, Grina 7/1, Moscow, 117216, Russian Federation
  • 3 Orenburg State University, Pobedy 13, Orenburg, 460352, Russian Federation
  • 4 RUDN University Miklukho, Maklaya 6, Moscow, 117198, Russian Federation
  • 5 Orenburg State Medical University, Sovetskaya 6, Orenburg, 460000, Russian Federation
Keywords
Alcohol; cobalt; Fetal alcohol syndrome; Manganese; Pregnancy
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/4417/
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