Objective. To substantiate approaches to diagnosing and managing patients with human papillomavirus (HPVassociated cervical diseases. Material and methods. The review included the data of foreign and Russian articles published in the past 10 years and found in electronic citation systems on this topic. Results. It has been pointed out that each of the diagnostic techniques, such as cytology, HPV test, and colposcopy, has advantages and disadvantages, which should be considered by a modern specialist. The tactics in the management of patients with LSIL and HSIL is determined by the type of a transformation area and by age. One of the approaches to managing patients with HPV can be antiviral/immunomodulatory therapy in combination with physiosurgical techniques. Conclusion. The review will allow a practitioner to find a rational approach to managing patients with HPVassociated genital diseases. © Bionika Media Ltd.