Substance P as a neuromodulator of cerebellar cholinergic systems

Substance P in low concentrations (10 -7 M) activates rat cerebellar neurons (in slices), while in high concentrations (10 -6 and 10 -5 M) this compound causes a biphasic response (excitation-inhibition). Substance P probably acts as the excitatory neurotransmitter in the cerebellum and produces modulatory effects (triggering and facilitation) on cerebellar cholinergic structures. Substance P reactivates cholinergic excitatory processes, while acetylcholine prevents substance P-induced inhibitory phase. The data suggest that the modulatory effects of substance P are realized via the feedback mechanisms.

Editors
-
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
11
Language
English
Pages
1035-1037
Status
Published
Department
-
Number
-
Volume
130
Year
2000
Organizations
  • 1 Department of Normal Physiology, Patrice Lumumba People's Friendship University, Moscow, Russian Federation
Keywords
Acetylcholine; Neuromodulator; Neuronal impulse activity; Neurotransmitter; Substance P
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/403/