Michael addition to unprotected 3-(2-nitrovinyl)indoles under the conditions of microwave synthesis

A novel highly efficient preparative method for the synthesis of substituted indoles using conjugate addition of nucleophiles to 3-(2-nitrovinyl)indoles has been developed. The addition of nucleophiles generated in the presence of a base from CH acids was investigated. The studied reactions proceed quickly and smoothly under the conditions of microwave activation and do not require protection of the indole nitrogen atom. © 2016 Springer Science+Business Media New York.

Authors
Aksenov A.V.1 , Aksenov N.A. 1, 2 , Skomorokhov A.A.1 , Aksenova I.V.1 , Gryaznov G.D.1 , Voskressensky L.G. 2 , Rubin M.A.1, 3
Publisher
Латвийский институт органического синтеза Латвийской академии наук / Springer New York Consultants Bureau
Number of issue
11
Language
English
Pages
923-927
Status
Published
Volume
52
Year
2016
Organizations
  • 1 North-Caucasus Federal University, 1а Pushkin St., Stavropol, 355009, Russian Federation
  • 2 Peoples’ Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, 117198, Russian Federation
  • 3 The University of Kansas, 1251 Wescoe Hall Dr., Lawrence, KS 66045-7582, United States
Keywords
Addition; Indole; Michael reaction; Nitroalkenes
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/4025/
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