Dissolution of Ketoprofen from Poly(Ethylene Glycol) Solid Dispersions

The effect of solid dispersions (SDs) on the solubility of the nonsteroidal anti-inflammatory drug ketoprofen was determined. Ketoprofen and its SDs with poly(ethylene glycol) PEG-400, -1000, -1500, -2000, and -3000 were studied. Dissolution of ketoprofen from the SDs increased by 1.2 – 1.8 times; the dissolution rate, by 1.7 – 2.4 times. The improved release of ketoprofen from the SDs was proposed to be due to several factors such as solubilization and amorphization of the compound and formation of intermolecular H-bonds. The results could be used to develop rapidly dissolving ketoprofen solid dosage forms. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

Authors
Belyatskaya A.V.1 , Krasnyuk I.I.1 , Jr , Stepanova O.I.1 , Kosheleva T.M.1 , Kudinova T.P.1 , Vorob’ev A.N. 2 , Maryanyan M.M.1
Journal
Pharmaceutical Chemistry Journal
Number of issue
12
Language
English
Pages
1001-1006
Status
Published
Link
External link
DOI
10.1007/s11094-019-01941-0
Volume
52
Year
2019
Organizations
  • 1 I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, 119991, Russian Federation
  • 2 People’s Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
Keywords
dissolution; ketoprofen; poly(ethylene glycol); solid dispersions
Date of creation
19.07.2019
Date of change
19.07.2019
Short link
https://repository.rudn.ru/en/records/article/record/38713/
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