Tris(2,6-dimethoxyphenyl)methyl carbenium ion as a charge derivatization agent for the analysis of primary amines by MALDI mass spectrometry

A novel derivatization method for the analysis of primary amines by MALDI mass spectrometry is proposed. Tris(2,6-dimethoxyphenyl) methyl carbenium cation reacts smoothly with primary amines, forming permanently charged adducts with the mass increment +359 Da and absorbance in the UV region. The approach was tested on a number of amines, including biologically active compounds and therapeutic agents. © 2016, Pleiades Publishing, Ltd.

Authors
Topolyan A.P.1 , Strizhevskaya D.A.1 , Slyundina M.S.2, 3 , Belyaeva M.A.1 , Ivanova O.M.1 , Korshun V.A.1, 2 , Ustinov A.V.1 , Mikhura I.V.1 , Formanovsky A.A.1 , Borisov R.S. 3, 4
Journal
Journal of Analytical Chemistry
Number of issue
14
Language
English
Pages
1326-1331
Status
Published
Link
External link
DOI
10.1134/S106193481614015X
Volume
71
Year
2016
Organizations
  • 1 Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russian Federation
  • 2 Gause Institute of New Antibiotics, Moscow, 119021, Russian Federation
  • 3 Topchiev Institute of Petrochemical Synthesis, Moscow, 119991, Russian Federation
  • 4 Peoples Friendship University of Russia, Moscow, 117198, Russian Federation
Keywords
amines; derivatization; MALDI mass spectrometry; trityl cation
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/3733/
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