Investigation of the efficacy and safety of a diindolylmethane-based drug in patients with cervical intraepithelial neoplasia grades 1-2 (CIN 1-2)

Objective. To investigate the efficacy and safety of the vaginal suppositories Cervicon-DIM (diindolylmethane) in patients with histologically confirmed neoplastic processes of the cervix uteri - cervical intraepithelial neoplasia grades 1-2 (CIN 1-2). Subject and methods. The randomized study enrolled 160 patients aged 18 to 45 years; the follow-up period was 3 months. The investigators analyzed clinical and laboratory data and evaluated the efficacy and safety of treatment with Cervicon-DIM versus placebo. Results. Cervicon-DIM was shown to contribute to the elimination of human papillomavirus infection and to the regression of mild and moderate neoplastic processes of the cervix uteri (CIN 1-2). Conclusion. It is appropriate to prescribe Cervicon-DIM as one suppository (100 mg) twice daily for 3 months to patients with human papillomavirus infection and those with CIN 1-2. © 2018, Bionika Media Ltd. All rights reserved.

Authors
Sukhikh G.T.1 , Ashrafyan L.A.2 , Kiselev V.I. 3 , Apolikhina I.A.4 , Maltseva L.I.5 , Suturina L.V.6 , Selivanov S.P.7 , Leonidova T.N.8 , Tskhay V.B.9 , Radzinskiy V.E. 10 , Ordiyants I.M. 11 , Bebneva T.N. 12 , Evtushenko I.D.13 , Udut V.V.14 , Kulagina N.V.15 , Baranov A.N.16 , Hasanov R.17 , Guryeva V.A.18 , Shamina I.V.19 , Karakhalis L.Y.20 , Muyzhnek E.L.21
Journal
Akusherstvo i Ginekologiya
Publisher
ООО «Бионика Медиа»
Number of issue
9
Language
Russian
Pages
91-98
Status
Published
Link
External link
DOI
10.18565/aig.2018.9.91-98
Year
2018
Organizations
  • 1 Academician of Russian Academy of Sciences, Ministry of Health of Russia, Ac. Oparina str. 4, Moscow, 117997, Russian Federation
  • 2 Institute of Oncogynecology and Mammology, National Medical Research Center of Obstetrics Gynecology and Perinatology, Ministry of Health of Russia, Ac. Oparina str. 4, Moscow, 117997, Russian Federation
  • 3 National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Ac. Oparina str. 4, Moscow, 117997, Russian Federation
  • 4 Department of Obstetrics Gynecology Perinatology and Reproductology I.M. Sechenov First Moscow State Medical University, Department of Aesthetic Gynecology and Rehabilitation and a day hospital, National Medical Research Center of Obstetrics Gynecology and Perinatology Ministry of Health of Russia, Ac. Oparina str. 4, Moscow, 117997, Russian Federation
  • 5 Obstetrics and Gynecology Department № 1, Kazan State Medical Academy Branch Russian Medical Academy of Continuing Postgraduate Education, Ministry of Health of Russia, Mushtari str. 11, Kazan, 422012, Russian Federation
  • 6 Department of Endocrinology State Medical University of Irkutsk State Medical Academy of Postgraduate Education of the Ministry of Health of Russia, Siberian Branch of the Russian Academy of Medical Sciences, Timiryazeva str. 16, Irkutsk, Russian Federation
  • 7 Department of Urology, Siberian State Medical University, NMU Medical diagnostic center, Moscow highway, 2, Tomsk, Russian Federation
  • 8 Ministry of Health of the Perm Krai, Sedova str. 8, Perm, Russian Federation
  • 9 Department of Perinatology Obstetrics and Gynecology, Medical Faculty, Krasnoyarsk State Medical University named after V.F. Voyno-Yasenetsky, P. Zheleznyaka str. 1, Krasnoyarsk, 660022, Russian Federation
  • 10 Department of Obstetrics and Gynecology with a Perinatology Course of the Medical Institute of the Peoples’ Friendship University of Russia subdivision of the Ministry of Education and Science of Russia, Department of Obstetrics Gynecology and Reproductive Medicine of the Advanced Medical Training Faculty of the Peoples’ Friendship University of Russia, Miklukho-Maklaya str. 6, Moscow, 117198, Russian Federation
  • 11 Department of Obstetrics and Gynecology with the course of Perinatology, Peoples’ Friendship University of Russia, Miklukho-Maklaya str. 6, Moscow, 117198, Russian Federation
  • 12 Peoples’ Friendship University of Russia, Ministry of Education and Science, Miklukho-Maklaya str. 21, bld. 3, Moscow, 117198, Russian Federation
  • 13 Department of Obstetrics and Gynecology of the State Medical University of the Siberian Federal University of Health Care of the Ministry of Health of Russia, Moscow highway, 2, Tomsk, Russian Federation
  • 14 RAS, E.D. Goldberg NIIFiRM, Lenin Ave. 3, Tomsk, Russian Federation
  • 15 Department of Obstetrics and Gynecology I.I. Mechnikov Northwestern State Medical University, Ministry of Health of Russia, St. Petersburg, Kirochnaya str. 41191015, Russian Federation
  • 16 Department of Obstetrics and Gynecology, Northern State Medical University, Arkhangelsk, Troitskiy Ave. 5163000, Russian Federation
  • 17 Kazan State Medical Academy Department of Oncology, Department of Oncology, Radiology and Palliative Medicine, Butlerova str. 36, Kazan, Russian Federation
  • 18 Russian Academy of Natural Sciences, Lyapidevskogo str. 1, Barnaul, Russian Federation
  • 19 Department of Obstetrics and Gynecology No. 2, Omsk State Medical University, Ministry of Health of Russia, Lenina str. 12, Omsk, 644043, Russian Federation
  • 20 Kuban State Medical University, Ministry of Health of Russia, Sedina str. 4, Krasnodar, 350007, Russian Federation
  • 21 MiraxBioPharma JSC., Valovaya str. 21, bld. 125, Moscow, Russian Federation
Keywords
Cervical intraepithelial neoplasia; Cervicon-DIM; Cervix uteri; Human papillomavirus
Date of creation
04.02.2019
Date of change
26.02.2022
Short link
https://repository.rudn.ru/en/records/article/record/36608/
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