Comparative experimental study of 5-ALA and 5-ALA Hexyl ester specific activity

A comparative experimental study of the specific activity of drugs based on 5-aminolevulinic acid (5-ALA) and its hexyl ester (5-ALA HE) was carried out. Their ability to induce the synthesis of photoactive protoporphyrin IX in the healthy tissues of the rabbit bladder when instilling the drug solutions at various concentrations has been estimated. It was shown that 5-ALA HE results in the induction and accumulation of PPIX in the rabbit bladder epithelium at much lower concentrations than 5-ALA. Thus, a significant increase in the fluorescence intensity in comparison with the control was achieved by instillation of 5-ALA HE solution in the rabbit' bladder at a concentration of only 0.0001% (fluorescence intensity 2.20±0.60 a.u.), and for 5-ALA - only when using a solution at a concentration of 0.3% (fluorescence intensity 2.60±1.02 a.u.). © 2018 Russian Photodynamic Association. All rights reserved.

Authors
Yakubovskaya R.I.1 , Pankratov A.A.1 , Filonenko E.V.1, 2 , Lukyanets E.A.3 , Ivanova-Radkevich V.I. 3, 4 , Trushin A.A.2 , Kaprin A.D. 1
Journal
Biomedical Photonics
Publisher
Russian Photodynamic Association
Number of issue
3
Language
Russian
Pages
43-46
Status
Published
Link
External link
DOI
10.24931/2413-9432-2018-7-3-43-46
Volume
7
Year
2018
Organizations
  • 1 P.Herzen Moscow Oncology Research Institute- Branch, National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russian Federation
  • 2 I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
  • 3 State Scientific Center, Scientific Research Institute Organic Intermediates and Dyes, Moscow, Russian Federation
  • 4 Peoples' Friendship University of Russia, RUDN University, Moscow, Russian Federation
Keywords
5-aminolevulinic acid; Bladder cancer; Fluorescence diagnosis; Hexyl ester of 5-aminolevulinic acid; Protoporphyrin IX
Date of creation
04.02.2019
Date of change
04.02.2019
Short link
https://repository.rudn.ru/en/records/article/record/36535/
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