CU42GE24NA4—A GIANT TRIMETALLIC SESQUIOXANE CAGE: SYNTHESIS, STRUCTURE, AND CATALYTIC ACTIVITY
Catalysts. MDPI AG. Vol. 8. 2018.
A novel method has been developed for the desymmetrization of aromatic dicarboxylic acids by employing an esterification reaction/conjugate addition of a carboxyl group to ynoates, which can trigger a coupling reaction. This one-pot cascade transformation, utilizing trialkylamines as alkyl sources for esterification, and ethyl propiolate as a protective or coupling reagent for carboxyl functions (hydrolysis, amidation, esterification, and thioesterification), leads to an asymmetric dicarbonyl target skeleton in a selective manner. © the Partner Organisations.