Convenient synthesis of functionalized cyclopropa[c]coumarin-1a-carboxylates

A simple method has been developed for the synthesis of cyclopropa[c]coumarins, which belong to the donor-acceptor cyclopropane family and, therefore, are promising substrates for the preparation of chromene-based fine chemicals. The method, based on the acetic acid-induced intramolecular transesterification of 2-arylcyclopropane-1,1-dicarboxylates, was found to be efficient for substrates containing hydroxy group directly attached to the aromatic ring. © 2018 by the Authors.

Authors
Ivanova O.A. 1 , Andronov V.A. 1 , Levina I.I.2 , Chagarovskiy A.O. 3 , Voskressensky L.G. 4 , Trushkov I.V. 3, 4
Journal
Molecules
Publisher
MDPI AG
Number of issue
1
Language
English
Status
Published
Link
External link
DOI
10.3390/molecules24010057
Number
57
Volume
24
Year
2019
Organizations
  • 1 Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie gory 1-3, Moscow, 119991, Russian Federation
  • 2 N. M. Emanuel Institute of Biochemical Physics, Russia Academy of Sciences, Kosygina 4, Moscow, 119334, Russian Federation
  • 3 Laboratory of Chemical Synthesis, Dmitry Rogachev National Research Center of Pediatric Hematology Oncology and Immunology, Samory Mashela 1, Moscow, 117997, Russian Federation
  • 4 Faculty of Science, RUDN University, Miklukho-Maklaya 6, Moscow, 117198, Russian Federation
Keywords
Coumarins; Donor-acceptor cyclopropanes; Heterocycles
Date of creation
04.02.2019
Date of change
04.02.2019
Short link
https://repository.rudn.ru/en/records/article/record/36155/
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