First synthesis and X-ray crystal structure of hexahydrobenzo[b]pyrido[3,4, 5-de]-1,6-naphthyridines

The reaction of 10-carboxamido tetrahydrobenzo[b][1,6]naphthyridines 1-3 with activated terminal alkynes in DMF/methanol resulted with the formation of hexahydrobenzo[b]pyrido[3,4,5-de]-1,6-naphthyridines 7-10- representatives of a new heterocyclic system.

Authors
Voskressensky L.G. 1 , Borisova T.N. 1 , Listratova A. 1 , Vorobiev I.V. 1 , Aleksandrov G.G. 2 , Varlamov A.V. 1
Journal
Journal of Heterocyclic Chemistry
Publisher
HeteroCorporation
Number of issue
6
Language
English
Pages
1207-1210
Status
Published
Link
External link
DOI
10.1002/JHET.5570420627
Volume
42
Year
2005
Organizations
  • 1 Organic Chemistry Department, Russian Peoples Friendship University, 6, Miklukho-Maklaya St., Moscow 117198, Russian Federation
  • 2 RAS Kurnakov Institute, 31, Leninsky pr., Moscow, Russian Federation
Keywords
2,3,3a,4,5,6 hexahydro 1h benzo[b]pyrido[3,4,5 de][1,6]naphthyridine; 2,3,3a,4,5,6 hexahydrobenzo[b]pyrido[3,4,5 de] 1,6 naphthyridine; 4 methyl 3 (2 oxopropyl) 2,3,3a,4,5,6 hexahydro 1h benzo[b]pyrido[3,4,5 de] 1,6 naphthyridin 1 one; ethyl 2 [4 isopropyl 1 oxo 2,3,3a,4,5,6 hexahydro 1h benzo[b]pyrido[3,4,5 de][1,6]naphthyridin 3 yl]acetate; ethyl [10 bromo 4 isopropyl 1 oxo 2,3,3a,4,5,6 hexahydro 1h benzo[b]pyrido[3,4,5 de] 1,6 naphthyridin 3 yl]acetate; ethyl [4 methyl 1 oxo 2,3,3a,4,5,6 hexahydro 1h benzo[b]pyrido[3,4,5 de] 1,6 naphthyridin 3 yl]acetate; heterocyclic compound; naphthyridine derivative; unclassified drug; article; carbon nuclear magnetic resonance; chemical structure; crystal structure; electrospray mass spectrometry; proton nuclear magnetic resonance; synthesis
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