Protective properties of synthetic peptides of outer meningococcal membrane

Peptide fragments of conservative sites of PorA, OpaB, and NspA proteins of the outer membrane of serogroup B meningococci were synthesized. These peptides caused a pronounced protective effect in immunized mice infected with virulent homologous and heterologous strains of serogroups B and A meningococci. The protective effect appreciably increased, if the studied peptides were associated in a polycomponent preparation, which can be used in the construction of meningococcal bivalent B+A vaccine. © Springer Science+Business Media, Inc. 2005.

Authors
Kotel'nikova O.V. 1 , Chibiskova O.V.1 , Nesmeyanov V.A.1 , Alliluev A.P. 2 , Vol'pina O.V.1 , Koroev D.O.1 , Zhmak M.N.1 , Titova M.A.1 , Ivanov V.T.1
Journal
Bulletin of Experimental Biology and Medicine
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
5
Language
English
Pages
593-595
Status
Published
Link
External link
DOI
10.1007/s10517-005-0353-8
Volume
139
Year
2005
Organizations
  • 1 M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
  • 2 Department of Microbiology, Russian University of Peoples' Friendship, Moscow, Russian Federation
Keywords
Meningococcus; Protective activity; Synthetic peptides
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/3492/
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