Matrix metalloproteinases of normal human tissues

This review considers biochemical properties of the family of matrix metalloproteinases (MMPs) of normal human tissues and the involvement of these enzymes in morphogenesis. Four main MMP subfamilies are characterized, and a group of other MMPs is described. Data on mechanisms of activation and inhibition of MMPs in certain tissues during various physiological processes (embryogenesis, angiogenesis, tissue growth and involution) are considered. Information about tissue inhibitors of MMP is presented, and the ability of these inhibitors to regulate the activity of MMPs is analyzed.

Authors
Khasigov P.Z.1 , Podobed O.V.1 , Ktzoeva S.A.1 , Gatagonova T.M.1 , Grachev S.V.1 , Shishkin S.S.2 , Berezov T.T. 3
Number of issue
2
Language
English
Pages
130-140
Status
Published
Volume
66
Year
2001
Organizations
  • 1 Sechenov Moscow Medical Academy, ul. Bol'shaya Pirogovskaya 2/6, Moscow, 119881, Russian Federation
  • 2 Research Center of Medical Genetics, Russian Academy of Medical Sciences, ul. Moskvorech'e 1, Moscow, 115478, Russian Federation
  • 3 Russ. Univ. of People's Friendship, ul. Miklukho-Maklaya 6, Moscow, 117198, Russian Federation
Keywords
Extracellular matrix; Matrix metalloproteinases; Tissue inhibitors of matrix metalloproteinases
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/347/