Expression of genes for redox-dependent glutathione S-transferase isoforms GSTP1-1 and GSTA4-4 in tumor cell during the development doxorubicin resistance

Expression of genes for redox-dependent glutathione S-transferase isoforms GSTP1-1 and GSTA4-4 in tumor cells K562, MCF-7, and SKOV-3 was studied during the development of resistance to doxorubicin. It was found that the development of resistance was accompanied by predominant increase in the expression of hGSTP1 gene in MCF-7 cells, and hGSTA4 gene in resistant K562/DOX and SKVLB cells. © Springer Science+Business Media, Inc. 2007.

Authors
Kalinina E.V. 1, 2 , Chernov N.N. 1 , Saprin A.N. 1 , Kotova Ya.N.1 , Remizov V.I.1 , Shcherbak N.P.1
Journal
Bulletin of Experimental Biology and Medicine
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
3
Language
English
Pages
328-330
Status
Published
Link
External link
DOI
10.1007/s10517-007-0102-2
Volume
143
Year
2007
Organizations
  • 1 Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Russian Federation
  • 2 Peoples’ Friendship University of Russia
Keywords
Doxorubicin; Drug resistance; Glutathione S-transferase isoforms GSTP1-1 and GSTA4-4
Date of creation
19.10.2018
Date of change
25.04.2023
Short link
https://repository.rudn.ru/en/records/article/record/3267/
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Article
De Vasconcellos M.C., Villavicencio A A.
Memorias do Instituto Oswaldo Cruz. Vol. 102. 2007. P. 242-243