A novel alkyne-induced recyclization of 4-hydroxymethyl or 4-formyl-1H-2,3-dihydroisoindoles-an effective pathway to substituted isobenzofurans

2-Alkyl or 2-benzyl-substituted 4-hydroxymethyl(formyl)isoindoles readily react with electron-deficient alkynes undergoing intramolecular cyclization to produce 1-aminomethyl-substituted isobenzofurans in good yields. © 2009 Elsevier Ltd. All rights reserved.

Publisher
Elsevier Ltd
Number of issue
34
Language
English
Pages
4851-4853
Status
Published
Volume
50
Year
2009
Organizations
  • 1 Organic Chemistry Department, Russian Peoples' Friendship University, 6, Miklukho-Maklaya St, Moscow, 117198, Russian Federation
Keywords
4 formyl 1h 2,3 dihydroisoindole derivative; alkyne derivative; isobenzofuran derivative; isoindole derivative; unclassified drug; article; chemical reaction; chemical structure; cyclization; synthesis; temperature measurement
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/2930/
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Blagonravov M.L., Frolov V.A.
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