Induction of Anti-Meningitis Immunity by Synthetic Peptides: II. Immunoactive Synthetic Fragments of the OpaB Protein from Neisseria meningitidis

Mice of various lines were immunized by 11 synthetic peptides that correspond to the sequences of fragments of the OpaB protein from the outer membrane of Neisseria meningitidis involving the known human T-helper epitopes and all the potential mouse T-helper epitopes calculated for the protein. The mice were immunized with the free peptides without their conjugation with a protein carrier. Most of the peptides were found to induce in mice the production of antipeptide antibodies. Mice protection against the experimental infection by a virulent strain of N. meningitidis of the B serotype was studied, and two peptides were shown to exert the most pronounced protective effect.

Authors
Koroev D.O.1 , Volpina O.M.1 , Zhmak M.N.1 , Kupriyanova M.A.1 , Nesmeyanov V.A.1 , Alliluev A.P. 2 , Kotel'nikova O.V.1 , Ivanov V.T.1
Editors
-
Publisher
-
Number of issue
1
Language
English
Pages
17-22
Status
Published
Department
-
Number
-
Volume
27
Year
2001
Organizations
  • 1 Shemyakin-Ovchinnikov Inst. B., Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, GSP-7, Moscow, 117871, Russian Federation
  • 2 Inst. of Gen. and Clinical Pathology, Peoples' Friendship Univ. of Russia, ul. Miklukho-Maklaya 6, Moscow, 117198, Russian Federation
Keywords
Immunogenicity; Neisseria meningitidis; OpaB; Protective effect; Synthetic peptides
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/293/