Polymorphism of the catalase and glutathione peroxidase genes and macrovascular complications in non-insulin-dependent diabetic hypertensives

Allelic and genotypic distributions of the polymorphic markers Cl 167T and Prol97Leu of the genes of catalase (CAT) and glutathione peroxidase (GPX1), respectively, were studied in patients with non-insulin-dependent diabetes mellitus (NIDDM) and hypertension without complications (the control group, n = 52) and with complications: myocardial infarction (MI, n = 53) or stroke (n - 50). No significant differences were found between complicated and uncomplicated patients with respect to the allelic or phenotypic distribution. Thus, there were no association between these polymorphic regions and either MI or stroke in hypertensive NIDDM patients.