A new approach towards the synthesis of pyrrolo[2,1-a]isoquinolines

Reaction of 5-bromo-2-methyl-8-nitro-1,2,3,4-tetrahydroisoquinoline with activated alkynes affords stable tetrahydropyrrolo[2,1-a]isoquinolin-4-ium ylides. Further reactions of ylide 2 gives access to substituted dihydropyrrolo[2,1-a]isoquinolines in good yields. © 2009 Elsevier Ltd. All rights reserved.

Authors
Voskressensky L.G. 1 , Listratova A.V. 1 , Bolshov A.V. 1 , Bizhko O.V. 1 , Borisova T.N. 1 , Varlamov A.V. 1
Journal
Tetrahedron Letters
Publisher
Elsevier Ltd
Number of issue
5
Language
English
Pages
840-842
Status
Published
Link
External link
DOI
10.1016/j.tetlet.2009.12.026
Volume
51
Year
2010
Organizations
  • 1 Organic Chemistry Department, the Russian Peoples' Friendship University, 6, Miklukho-Maklaia St, Moscow, 117198, Russian Federation
Keywords
pyrrolo[2,1 a]isoquinoline derivative; article; chemical reaction; chemical structure; substitution reaction; synthesis
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/2808/
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