Effects of human defensin-α1 on trypanosoma cruzi trypomastigotes in vitro

Human defensin-α1 is a biologically active peptide exhibiting a dose-dependent trypanocidal effect in vitro against trypomastigotes and amastigotes of Trypanosoma cruzi line Tulahuen. This effect is determined by fragmentation of parasite DNA reducing the capacity of passaged T. cruzi to invade HeLa cells. © 2010 Springer Science+Business Media, Inc.

Authors
Kleschenko Y.E. 2 , Karpenko L.P. 2 , Villalta F.1
Journal
Bulletin of Experimental Biology and Medicine
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
6
Language
English
Pages
731-733
Status
Published
Link
External link
DOI
10.1007/s10517-010-1038-5
Volume
149
Year
2010
Organizations
  • 1 Department of Microbiology and Immunology, Meharry Medical College, Nashville, TN, United States
  • 2 Department of Microbiology and Virology, Russian University of Peoples' Friendship, Moscow, Russian Federation
Keywords
Chagas disease; Defenzin-α1; Trypanosoma cruzi; Trypomastigotes
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/2695/
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