Particulate characterization of herbal extracts for its standardization and quality control

We have examined herbal extracts of Hippophae rhamnoides L. (sea buckthorn), Arnica montana L. (arnica), Malva sylvestris L. (mallow). Sea buckthorn extract is an antiviral agent, arnica extract - anti-inflammatory agent and mallow extract - expectorant. MasterSizer 2000 and ZetaSizer Nano ZS (Malvern Instruments) were applied. Size spectra of herbal extracts were too irregular and specific for each sample. Dried extract of Arnica foliosa Nutt. characterize by prevalence of 1 |um and 3 urn particles by number and of 40 |um and 140 |um particles by volume. After dissolving only 1 \im and 3 um particles were detected. Dried extract of Malva sylvestris L. characterize by prevalence of 1 |um particles by number but its volume distribution was too irregular (from 10 |um to 800 |um). In samples of sea buckthorn extract we have detected three groups of particles with size 50 jum, 150 urn and 200 urn Inclusion of sea buckthorn extract in plaster mass caused disappearing of 50 urn and 150 |um particles with prevalence only of 200 |um particles. Poly dispersive system changes into monodispersive due to inclusion of dried extract in plaster mass. It is a basic precondition of uniform distribution of dried extract particles which depends on biological activity and very important in application dosage forms technology. © 2011.

Authors
Editors
-
Conference proceedings
Publisher
Italian Association of Chemical Engineering - AIDIC
Number of issue
-
Language
English
Pages
691-696
Status
Published
Department
-
Link
-
Number
-
Volume
24
Year
2011
Organizations
  • 1 Peoples' Friendship University of Russia, Miklukho-Maklaya str. 6, 117198, Moscow, Russian Federation
  • 2 All-Russia Scientific Research Institute of the Medicinal and Aromatic Herbs (VILAR), Russian Federation
Keywords
Antiviral agents; Bioactivity; Extraction; Plants (botany); Anti-inflammatory agents; Dispersive systems; Herbal extract; Hippophae rhamnoides; Malvern instruments; Particulate characterizations; Uniform distribution; Volume distributions; Plant extracts
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/2611/