Expression of genes of glutathione transferase isoforms GSTP1-1, GSTA4-4, and GSTK1-1 in tumor cells during the formation of drug resistance to cisplatin

We studied the expression of genes encoding glutathione-S-transferase isoforms GSTP1-1, GSTA4-4, and GSTK1-1 during the development of the resistance of human erythroleukemia (K562), mammary adenocarcinoma (MCF-7) and ovary adenocarcinoma (SKOV-3) cells to cisplatin (CDDP). It was found that drug resistance development in all three strains of tumor cells is associated with signifi cant increase in hGSTP1 and hGSTA4 gene expression, whereas increased hGSTK1 gene expression was detected only in resistant K562/CDDP and MCF-7/CDDP cells. © 2012 Springer Science+Business Media New York.

Authors
Kalinina E.V. 1 , Berozov T.T. 1 , Shtil A.A.2 , Chernov N.N. 1 , Glasunova V.A.2 , Novichkova M.D. 1 , Nurmuradov N.K. 1
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
1
Language
English
Pages
64-67
Status
Published
Volume
154
Year
2012
Organizations
  • 1 People's Friendship University of Russia, MockBa, Russian Federation
  • 2 N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russian Federation
Keywords
cisplatin; drug resistance of tumor cells; gene expression; glutathione-S-transferase isoforms
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/2248/
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