An efficient synthesis of isomeric 1-(1-Alkyl-1H-pyrazolyl) ethanones

A simple and versatile general method for the preparation of N-substituted 3-, 4-, or 5-acetylpyrazoles from corresponding acids via hydrolysis and decarboxylation of substituted diethyl [(1-alkyl-1H-pyrazolyl)carbonyl]malonates was developed. Title compounds were prepared in three steps without isolation of intermediates in 48-82% overall yield. © 2012 HeteroCorporation.

Publisher
HeteroCorporation
Number of issue
6
Language
English
Pages
1422-1424
Status
Published
Volume
49
Year
2012
Organizations
  • 1 G.S Petrov Institute of Plastics, Perovskiy Proezd 35, Moscow 111024, Russian Federation
  • 2 People's Friendship University of Russia, Moscow 117198, Russian Federation
Keywords
3 acetylpyrazole derivative; 4 acetylpyrazole derivative; 5 acetylpyrazole derivative; pyrazole derivative; unclassified drug; article; chemical structure; decarboxylation; hydrolysis; isomer; reaction analysis; structure analysis; synthesis
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/2245/