Role of serotoninergic structures in coordination of electric activity in the gastroduodenal complex

Myoelectric activity in various portions of the stomach and duodenum in normal and after vagotomy and intravenous injection of serotonin adipinate was studied in acute experiments on cats. Vagotomy disturbed coordination of myoelectric activity in the stomach and duodenum. Intravenous injection of serotonin adipinate restored coordination and increased myoelectric activity in the stomach, particularly, in the pylorus. Under these conditions the pacemaker of myoelectric activity in the gastric corpus and autonomic regulation of the duodenum were preserved. Intravenous injection of serotonin adipinate most significantly changed myoelectric activity in the pylorus. Myoelectric activity in the cardia increased after vagotomy against the background of serotonin adipinate. Our findings suggest that serotoninergic structures maintain functional heterogeneity of digestive organs and coordinate their interrelationships.

Authors
Bilibin D.P. 1, 2, 3 , Shevelev O.A. 1, 2, 3 , Khodorovich N.A. 1, 2, 3 , Zav'yalov A.V. 1, 2, 3 , Gorpinich A.B. 1, 2, 3 , Privalova I.L. 1, 2, 3 , Durneva O.M. 1, 2, 3
Editors
-
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
3
Language
English
Pages
229-231
Status
Published
Department
-
Number
-
Volume
133
Year
2002
Organizations
  • 1 Russian University of People's Friendship, Russian Federation
  • 2 Kursk State Medical University, Russian Federation
  • 3 Orel State University, Russian Federation
Keywords
Electric activity; Gastroduodenal complex; Serotoninergic structures
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/183/