Pentamethine cyanine dyes with alkynyl group as perspective structure for conjugation with targeting moiety

We report a modified carbocyanine-based asymmetric fluorescent dye, suitable for the azide-alkyne cycloaddition reaction, that possesses promising photochemical properties (Φfl = 0,49). As an example of usage of the new fluorophore, it was conjugated to a ligand targeting prostate-specific membrane antigen (PSMA), one of the widely utilized prostate cancer markers.

Authors
Uspenskaia Anastasiia A. 1 , Doroshenko Irina A. 1 , Popovicheva Kseniia A. 2 , Shmychkov Nazar V. 1 , Pryakhina Ekaterina V. 3 , Shafikov Radik R. 1, 4 , Skvortsov Dmitrii A. 4 , Beklemishev Mikhail K. 1 , Zaborova Olga V. 1 , Podrugina Tatiana A. 1 , Machulkin Aleksei E. 1, 5 , Beloglazkina Elena K. 1
Journal
Bioorganic and Medicinal Chemistry Letters
Publisher
Elsevier Ltd
Language
English
Pages
130025
State
Published
Link
External link
DOI
10.1016/J.BMCL.2024.130025
Volume
115
Year
2025
Organizations
  • 1 Lomonosov Moscow State University, Chemistry Dept.
  • 2 Lomonosov Moscow State University, Fundamental Physical and Chemical Engineering Dept.
  • 3 National Research University Higher School of Economics, Biology and Biotechnology Dept.
  • 4 Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences
  • 5 Department for Biochemistry, People’s Friendship University of Russia Named after Patrice Lumumba (RUDN University)
Keywords
Cyanine dyes; Click reaction; Asymmetric carbocyanine; Photochemistry
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