In Vitro and In Vivo Biodegradation of Silk Fabric Scaffolds

Abstract: Biodegradation of natural silk scaffolds made from gauze and satin fabrics was studied both in vitro and in vivo. Experiments were conducted using phosphate-buffered saline (PBS) and Fenton’s reagent to model degradation. Samples demonstrated high stability in the model of physiological conditions and varying degradation rates in oxidative stress. In vivo studies in rats showed good biocompatibility of the scaffolds and a gradual reduction in inflammatory responses. The findings highlight the potential of silk scaffolds for use in various areas of regenerative medicine. © Pleiades Publishing, Ltd. 2025.

Authors
Agapov I.I. , Podbolotova E.I. , Kirsanova L.A. , Grudinin N.V. , Pashutin A.R. , Agapova O.I. , Efimov A.E. , Lyundup A.V. , Gautier S.V.
Journal
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections / translated from Russian
Language
English
State
Published
Link
External link
DOI
10.1134/S0012496624600519
Year
2025
Organizations
  • 1 Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation, Moscow, Russian Federation
  • 2 Moscow Institute of Physics and Technology, Dolgoprudny, Russian Federation
  • 3 Рeoples’ Friendship University of Russia, Moscow, Russian Federation
  • 4 Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Moscow, Russian Federation
Keywords
biocompatibility; biodegradable materials; regenerative medicine; silk scaffolds; tissue engineering
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