ctDNA transiting into urine is ultrashort and facilitates noninvasive liquid biopsy of HPV+ oropharyngeal cancer

BACKGROUND. Transrenal cell-free tumor DNA (TR-ctDNA), which transits from the bloodstream into urine, has the potential to enable noninvasive cancer detection for a wide variety of nonurologic cancer types.

Authors
Bhambhani Chandan 9 , Kang Qing 9 , Hovelson D.H. 10, 11 , Sandford Erin 9 , Olesnavich Mary 9 , Dermody S.M. 12 , Wolfgang Jenny 9 , Tuck K.L. 9 , Brummel Collin 12 , Bhangale A.D. 12 , He Kuang 9 , Gutierrez M.G. 13 , Lindstrom R.H. 9 , Liu Chia-Jen 11 , Tuck Melissa 9 , Kandarpa Malathi 9 , Mierzwa Michelle , Casper Keith 12 , Prince M.E. 12 , Krauss J.C. 9 , Talpaz Moshe 9 , Henry N.L. 9 , Giraldez M.D. 9 , Ramnath Nithya 9 , Tomlins S.A. 11 , Swiecicki P.L. 9 , Brenner J.C. 12 , Tewari Muneesh 9
Journal
JCI Insight
Issue number
6
Language
English
State
Published
Volume
9
Year
2024
Organizations
  • 1 Department of Internal Medicine, Division of Hematology/Oncology,
  • 2 Department of Computational Medicine & Bioinformatics,
  • 3 Michigan Center for Translational Pathology,
  • 4 Department of Otolaryngology,
  • 5 Department of Internal Medicine,
  • 6 Department of Pathology,
  • 7 Department of Radiation Oncology, and
  • 8 Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA.
  • 9 Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Rocío, Consejo Superior de Investigaciones Científicas, University of Seville, Seville, Spain.
  • 10 Department of Urology,
  • 11 Department of Pharmacology,
  • 12 Center for Computational Biology and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
  • 13 Department of Biomedical Engineering, and
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