MORPHOLOGICAL EVALUATION OF THE EFFECTIVENESS OF TREATING INFECTED WOUNDS WITH HIGH-INTENSITY PULSED BROADBAND IRRADIATION; [МОРФОЛОГИЧЕСКАЯ ОЦЕНКА ЭФФЕКТИВНОСТИ ЛЕЧЕНИЯ ИНФИЦИРОВАННЫХ РАН ВЫСОКОИНТЕНСИВНЫМ ИМПУЛЬСНЫМ ШИРОКОПОЛОСНЫМ ОБЛУЧЕНИЕМ]

The objective of this study was to investigate the effectiveness of high-intensity pulsed broadband irradiation in treating infected wounds. A morphological study was conducted on wound specimens from 105 Wistar rats, in which infected wounds were experimentally induced (three groups). The first group was treated with high-intensity pulsed broadband irradiation, the second group received traditional ultraviolet irradiation, and the third group was treated only with antiseptics. Monitoring was performed before treatment, on the 7th, 14th, and 21st days of treatment. Non-parametric statistical methods were used for data analysis. Prior to treatment, the wounds exhibited signs of the acute inflammation phase. By the 7th day, the first group's wounds were in the proliferation phase. In the second and third groups, edema and infiltration persisted. By the 14th day, the first group's wounds showed signs of granulation tissue formation and transition to the regeneration stage. In the second group, there was a reduction in infiltration, the appearance of new capillaries, and an increase in fibroblasts. In the third group, inflammatory symptoms persisted. By the 21st day, the first group showed remodeling of connective tissue with signs of delicate scar formation. In the second group, signs of connective tissue remodeling were observed, while in the third group, there was reduced infiltration with slow formation of new vessels. Thus, the use of high-intensity pulsed broadband irradiation in the early stages effectively mitigates inflammation, activates local immune response, and accelerates reparative processes. © 2024 Russian Photodynamic Association. All rights reserved.