Novel Non-Toxic Highly Antibacterial Chitosan/Fe(III)-Based Nanoparticles That Contain a Deferoxamine—Trojan Horse Ligands: Combined Synthetic and Biological Studies

In this study, we prepared chitosan/Fe(III)/deferoxamine nanoparticles with unimodal size distribution (hydrodynamic diameter ca. 250 nm, zeta potential ca. 32 mV). The elaborated nanoparticles are characterized by outstanding in vitro and in vivo antibacterial activity, which exceeds even that of commercial antibiotics ampicillin and gentamicin. Moreover, the nanoparticles are non-toxic. We found that the introduction of iron ions into the chitosan matrix increases the ability of the resulting nanoparticles to disrupt the integrity of the membranes of microorganisms in comparison with pure chitosan. The introduction of deferoxamine into the obtained nanoparticles sharply expands their effect of destruction the bacterial membrane. The obtained antibacterial nanoparticles are promising for further preclinical studies. © 2023 by the authors.

Authors
Khubiev O.M. , Esakova V.E. , Egorov A.R. , Bely A.E. , Golubev R.A. , Tachaev M.V. , Kirichuk A.A. , Lobanov N.N. , Tskhovrebov A.G. , Kritchenkov A.S.
Journal
Publisher
MDPI
Number of issue
3
Language
English
Status
Published
Number
870
Volume
11
Year
2023
Organizations
  • 1 Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
  • 2 Metal Physics Laboratory, Institute of Technical Acoustics NAS of Belarus, Vitebsk, 210009, Belarus
Keywords
antibacterial activity; chitosan; deferoxamine; iron(III); nanoparticles; toxicity
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