Reperfusion Therapy in Pediatric Ischemic Stroke: the Pediatric Thrombolysis Protocol at the Primary Center of Pediatric Stroke in Moscow

SUMMARY. In recent years, the number of diagnosed cases of arterial ischemic stroke (AIS) in children has increased significantly. According to the Center for the Treatment of Cerebrovascular Pathology in Children and Adolescents (primary center of children's stroke) at Morozov city children hospital, the in-cidence of vascular brain diseases in children in Moscow was 6.59/100 000 in 2015, 6.51/100 000 in 2016, 6,43/100 000 in 2017, 5.86/100,000 in 2018, 6,69/100 000 in 2019 and 10,95/100 000 in 2020. The increase in the frequency of detection of acute ischemic stroke (AIS) in children and adolescents is primarily asso-ciated with improved diagnosis (detection of cerebral vascular abnormalities) and the availability of care to patients with cerebrovascular diseases at various stages of medical care. AIS thrombolytic therapy is the most effective treatment in adults. Currently, there are no available high level recommendations for thrombolytic therapy in children. In March 2018, the Center for the Treatment of Cerebrovascular Pathology in Children and Adolescents at Morozov city children hospital began using this therapy. Be-tween 2018 and 2020, 136 children were managed with AIS. Of these patients, 15 children were managed with Thrombolysis. The authors present a review of literature, analysis of local experience and a pediatric Thrombolysis protocol based on reviewed international and local literature. © 2022, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.