PHOTODYNAMIC THERAPY IN TREATMENT OF SQUAMOUS CELL CARCINOMA OF ORAL CAVITY WITH CHLORINE е6 PHOTOSENSITIZER WITH LONG-TERM FOLLOW UP; [РЕЗУЛЬТАТЫ ЛЕЧЕНИЯ БОЛЬНЫХ РАКОМ ПОЛОСТИ РТА ПРИ ПОМОЩИ ФОТОДИНАМИЧЕСКОЙ ТЕРАПИИ С ФОТОСЕНСИБИЛИЗАТОРОМ НА ОСНОВЕ ХЛОРИНА е6]

Photodynamic therapy is an effective method for treating superficial forms of malignant neoplasms, characterized by a minimal risk of damage to normal tissues. In this study, we presented our experience of treating cancer of the oral mucosa using photodynamic therapy, and analyzed the immediate and long-term results of treatment. 38 patients with squamous cell carcinoma of oral cavity mucosa, with a depth of invasion no more than 7 mm, were included in the study. All patients underwent photodynamic therapy with chlorine е6 based photosensitizer. Photosensitizers were administered intravenously 3 hours before irradiation, at a dosage of 1 mg/kg of the patient’s weight. Photodynamic therapy was performed with the following parameters: P – 1.0 W, Ps – 0.31 W/cm2, E – 300 J/cm2. The area of one irradiation field ranged 1.0-2.0 cm2. Treatment effect was evaluated by RECIST 1.1. Overall survival, cancer-specific survival, and disease-free survival were calculated using Kaplan-Meier curves. Evaluation of adverse events was made by СTCAE 5.0 criteria. At 35 (92.1%) out of 38 cases, complete regression was observed after photodynamic therapy. Among them in 3 out of 35 patients relapse was diagnosed in 11.5 to 43.2 months. The total number of patients who didn’t respond to treatment was 6 (15.8%). Follow-up period was 4.2-87.3 months. (mean 42.9). 34 (89.5%) out of 38 patients are alive, 1 (2.6%) died from progression, and three died from other causes. The 5-year overall survival rate was 82.1%, cancer-specific survival rate was 97.0%, and disease-free survival rate was 81.1%. Among the factors significantly (p < 0.05) influencing relapse-free survival: depth of invasion < 5 mm (p – 0.013) and the presence of leukoplakia (p – 0.007). When assessing cancer-specific survival, factors worsening the prognosis were: age >70 years (p – 0.034) and the presence of leukoplakia (p – 0.007). Photodynamic therapy is an alternative treatment method of oral cancer superficial lesions, in case of proper assessment of primary lesion and in case of possibility of full irradiation of the tumor. Moreover, after using photodynamic therapy, the underlying connective-muscular structures are preserved, which promotes rapid healing with minimal scarring, the functions of the affected organ remain intact, and cosmetic defects do not form. © 2024 Russian Photodynamic Association. All rights reserved.

Authors
Panaseykin Y.A. , Kapinus V.N. , Filonenko E.V. , Polkin V.V. , Sevrukov F.E. , Smirnova M.A. , Isaev P.A. , Ivanov S.A. , Kaprin A.D.
Publisher
Russian Photodynamic Association
Number of issue
1
Language
English
Pages
28-38
Status
Published
Volume
13
Year
2024
Organizations
  • 1 A. Tsyb Medical Radiological Research Center, the Ministry of Health of the Russian Federation, branch of the National Medical Research Radiological Center, Obninsk, Russian Federation
  • 2 P. Hertsen Moscow Oncology Research Institute, the Ministry of Health of the Russian Federation, branch of the National Medical Research Radiological Center, Moscow, Russian Federation
  • 3 Obninsk Institute for Nuclear Power Engineering, Obninsk, Russian Federation
  • 4 Рeoples Friendship University of Russia, RUDN University, Moscow, Russian Federation
  • 5 National Medical Research Radiological Center, the Ministry of Health of the Russian Federation, Obninsk, Russian Federation
Keywords
leukoplakia; photodynamic therapy; prognosis factors for oral cancer; squamous cell carcinoma of the oral cavity; survival rate for oral cancer
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