THE ROLE OF MEMBRANE TRANSPORT PROTEINS IN 5-ALK-INDUCED ACCUMULATION OF PROTOPORPHYRIN IX IN TUMOR CELLS; [РОЛЬ МЕМБРАННЫХ ПЕРЕНОСЧИКОВ В НАКОПЛЕНИИ 5-АЛК-ИНДУЦИРОВАННОГО ПРОТОПОРФИРИНА IX В ОПУХОЛЕВЫХ КЛЕТКАХ]

Features of the expression of membrane importers of 5-ALA, as well as transporters involved in the removal of photoactive precursors of protoporphyrin IX (PPIX) (uro-, copro- and protoporphyrinogens), may cause differences in the effectiveness of photodynamic therapy of malignant neoplasms using 5-aminolevulinic acid (5-ALA). Increased expression of ALA transporters is associated with an increase in the intensity of PPIX synthesis. When the expression of PPIX exporters increases, there is a decrease in PPIX concentration. The review describes the main transporters of 5-ALA, uro-, copro- and protoporphyrinogens, provides data on their expression in various tissues, and discusses the possibility of predicting the effectiveness of photodynamic therapy considering the expression of the corresponding transport proteins in malignant tissues. © 2024 Russian Photodynamic Association. All rights reserved.

Authors
Ivanova-Radkevich V.I. , Kuznetsova O.M. , Filonenko E.V.
Publisher
Russian Photodynamic Association
Number of issue
2
Language
English
Pages
43-48
Status
Published
Volume
13
Year
2024
Organizations
  • 1 Peoples’ Friendship University of Russia (RUDN University), Moscow, Russian Federation
  • 2 P.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC, The Ministry of Health of the Russian Federation, Moscow, Russian Federation
Keywords
5-aminolevulinic acid; photodynamic therapy; protoporphyrin IX; transmembrane transporters
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