Recent Advances in the Synthesis of Rosettacin

Camptothecin and its analogues show important antitumor activity and have been used in clinical studies. However, hydrolysis of lactone in the E ring seriously attenuates the antitumor activity. To change this situation, aromathecin alkaloids are investigated in order to replace camptothecins. Potential antitumor activity has obtained more and more attention from organic and pharmaceutical chemists. As a member of the aromathecin alkaloids, rosettacin has been synthesized via different methods. This review summarizes recent advances in the synthesis of rosettacin. © 2024 by the authors.

Authors
Tang X. , Jiang Y. , Song L. , Van Der Eycken E.V.
Journal
Molecules
Publisher
MDPI AG
Issue number
10
Language
English
State
Published
Link
External link
DOI
10.3390/MOLECULES29102176
Number
2176
Volume
29
Year
2024
Organizations
  • 1 College of Science, Nanjing Forestry University, Nanjing, 210037, China
  • 2 Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, China
  • 3 Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, Leuven, B-3001, Belgium
  • 4 Peoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya Street 6, Moscow, 117198, Russian Federation
Keywords
antitumor; aromathecin; camptothecin; heterocycle; rosettacin
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