On some changes in the myocardium of guinea pigs with protein sensitization

Guinea pigs were sensitized by three subcutaneous injections of 0.1 ml native horse serum at 2-day intervals, 21 days after the third injection the animals developed marked sensitization to this antigen which was manifested by anaphylactic reaction to the subcutaneous challenge with this antigen. At this time, the myocardium of the sensitized animals showed signs of extra- and intracellular oedema, a sharp increase in the number of lysosomes, damage of their membranes 2.1/2 months after sensitization the animals showed no anaphylactic reaction to the challenge dose of the antigen. There were few lysosomes in the myocardium and their membranes were intact. It is suggested that the intensity of lysosomal membrane damage is associated with the intensity of the anaphylactic reaction. It is suggested that the intensity of lysosomal membrane damage is associated with the intensity of the anaphylactic reaction.

Authors
Frolov V.A. 1 , Derx H.1 , Riguer P.1
Number of issue
9
Language
Russian
Pages
17-22
Status
Published
Volume
41
Year
1979
Organizations
  • 1 P. Lumumba Univ. Friendship Peoples, Moscow
Keywords
protein; acid phosphatase; antiserum; guinea pig; heart; heart muscle; histology; sensitization; theoretical study; anaphylaxis; animal; article; cytochemistry; cytoplasm; electron microscopy; enzymology; heart muscle; horse; hypersensitivity; immunology; lysosome; metabolism; pathology; ultrastructure; Acid Phosphatase; Anaphylaxis; Animal; English Abstract; Guinea Pigs; Histocytochemistry; Horses; Hypersensitivity; Immune Sera; Lysosomes; Microscopy, Electron; Myocardium; Organoids
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/1594/