PHOTODYNAMIC THERAPY OF BOWEN’S DISEASE; [ФОТОДИНАМИЧЕСКАЯ ТЕРАПИЯ ПАЦИЕНТОВ С БОЛЕЗНЬЮ БОУЭНА]

Bowen’s disease is a form of non-invasive (insitu) squamous cell skin cancer localized in the non-genital area. Russian and European clinical guidelines include photodynamic therapy (PDT) in the standard of care for patients with Bowen’s disease. In the present review, the efficacy and safety profile of different PDT regimens for Bowen’s disease are analyzed according to the available literature data. PDT can be used to treat large Bowen’s disease lesions localized in areas of the body characterized by severe healing and in cases where surgery is not feasible. Analysis of the results of studies shows that PDT is superior in efficacy and cosmetic results to traditional local treatments such as 5-fluorouracil or cryotherapy. In all analyzed studies in patients with Bowen’s disease, PDT achieved a significant clinical effect. Complete regression of pathologic foci was achieved in 67-100% of patients. In studies evaluating the recurrence rate of Bowen’s disease after PDT, this value ranged from 2-28% with the range of 6-18% in most of the studies. Most often, 5-aminolevulinic acid and its methyl ester are used for PDT in Bowen’s disease. According to some researchers, aminolevulinic acid allows to achieve a more long-term positive clinical effect with a lower incidence of painful reactions during treatment. © 2023 Russian Photodynamic Association. All rights reserved.

Authors
Filonenko E.V. , Ivanova-Radkevich V.I.
Publisher
Russian Photodynamic Association
Number of issue
4
Language
English
Pages
22-29
Status
Published
Volume
12
Year
2023
Organizations
  • 1 P.A. Herzen Moscow Oncology Research Center, Branch of FSBI NMRRC, Ministry of Health of the Russian Federation, Moscow, Russian Federation
  • 2 Peoples’ Friendship University of Russia (RUDN University), Moscow, Russian Federation
Keywords
5-aminolevulinic acid; 5-aminolevulinic acid methyl ester; Bowen’s disease; photodynamic therapy
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