Abnormal uterine bleeding and obesity: current paradigm

Abnormal uterine bleeding (AUB) remains one of the most common gynecological disorders that reduce the quality of life and reproductive potential in women. Obesity is recognized as an independent risk factor for the development of AUB associated with irregular endometrial proliferation (endometrial hyperplasia and endometrial cancer), ovulatory dysfunction and disease recurrence. The role of obesity in the pathogenesis of AUB due to endometrial dysfunction is an interesting and understudied aspect. Chronic adipose tissue inflammation is mechanistically linked to metabolic disease and organ tissue complications in overweight and obese women. Despite its minor nature, low-grade adipose tissue inflammation negatively impacts remote organ functions, thus being a cause of obesity complications. The results of recent studies suggest that obesity creates conditions for a proinflammatory environment in the endometrium during menstrual bleeding, which may inhibit endometrial regeneration and increase the volume of menstrual blood loss. © 2023, Dynasty Publishing House. All rights reserved.