N-propargyl aza-Claisen rearrangement in the synthesis of heterocycles

Pericyclic reactions present a convenient tool for constructing heterocyclic systems. They make possible to obtain quite complex structures in one step with high yields and stereoselectivity. A special position in this series is assigned to the named reactions of [3,3]-sigmatropic transformations, including the aza-Claisen one. This rearrangement lately found its brilliant continuation in N-propargyl variant. In the present short review we have tried to provide an overview of the practical application of N-propargyl aza-Claisen rearrangement in the construction of pyrrole, pyridine and medium aza-heterocycle derivatives focusing mainly on literature data on the XXI century. © 2022 Elsevier Ltd