Ciprofloxacin chitosan conjugate: combined antibacterial effect and low toxicity

Ultrasound-mediated reaction of chitosan with ciprofloxacin in the presence of N,N'-dicyclohexylcarbodiimide in water gives the chitosan–ciprofloxacin conjugates of carboxamide type. The conjugates show a mediate antibacterial effect and reduced cytotoxicity. © 2022

Authors
Egorov A.R. , Kurasova M.N. , Khubiev O. , Bogdanov N.A. , Tskhovrebov A.G. , Kirichuk A.A. , Khrustalev V.N. , Rubanik V.V.Jr. , Kritchenkov A.S.
Journal
Mendeleev Communications
Publisher
Royal Society of Chemistry
Issue number
6
Language
English
Pages
774-776
State
Published
Link
External link
DOI
10.1016/J.MENCOM.2022.11.022
Volume
32
Year
2022
Organizations
  • 1 Peoples Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
  • 2 N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russian Federation
  • 3 Institute of Technical Acoustics, National Academy of Sciences of Belarus, Vitebsk, 210009, Belarus
Keywords
antibacterial activity; carboxamides; chitosan; ciprofloxacin; conjugates; toxicity; ultrasound treatment
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