Coexposure of heavy metals and piracetam destroys adaptive behaviour

In experiments on rats, it was found that lead, cadmium and cobalt salts inhibit the acquisition of an avoidance responses. Cases of increased neurotoxic effect of heavy metals on learning and memory in rats with their combined administration with piracetam have been noted. Ascorbic acid counteracts this neurotoxic impact of the heavy metals and piracetam cooexposure on the adaptive behaviour.

Authors
Karpukhina Olga 1, 2 , Kalinina Irina 2 , Antonyan Arpine 3 , Inozemtsev Anatoly 1
Publisher
International Society for Clinical Physiology and Pathology
Issue number
1
Language
English
Pages
21-26
State
Published
Volume
2
Year
2023
Organizations
  • 1 Lomonosov Moscow State University
  • 2 Semenov Institute of Chemical Physics RAS
  • 3 RUDN University
Keywords
heavy metals; piracetam; ascorbic acid; learning; memory
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