Expression of vascular endothelial growth factor in bone development and bone tumors

Vascular endothelial growth factor (VEGF) is a homodimeric heparin-binding protein (34-42 kDa), which induces formation of new blood vessels (angiogenesis). VEGF-mediated capillary invasion is an essential signal that regulates growth plate morphogenesis and triggers cartilage remodeling. Thus, VEGF is essential coordinator of chondrocyte death, chondroclast function, extracellular matrix remodeling, angiogenesis and bone formation in the growth plate. VEGF expression in untreated osteosarcoma is predictive for pulmonary metastasis and poor prognosis. VEGF concentration in the serum of patients with malignant bone tumors (osteosarcoma, Ewing's tumor) increased in comparison with norm and benign tumors. VEGF expression in the serum of patients with osteosarcoma associated with the development of metastasis and without metastasis period. The results of investigation indicate the existence of dependence between VEGF expression and degree of tumor malignancy and metastasis. These results testify probable participation of VEGF in biology of the tumor-transformed tissue.

Authors
Kuznetsova O.M. 1 , Kushlinski N.E.2 , Berezov T.T. 1
Editors
-
Publisher
Russian Academy of Medical Sciences
Number of issue
4
Language
Russian
Pages
360-373
Status
Published
Department
-
DOI
-
Number
-
Volume
49
Year
2003
Organizations
  • 1 People's Friendship University, Moscow, Russian Federation
  • 2 Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russian Federation
Keywords
Angiogenesis; Chondrosarcoma; Ewing's tumor; Giant cell tumor; Osteosarcoma; Vascular endothelial growth factor
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/119/