Different Trajectories for Diabetes Mellitus Onset and Recovery According to the Centralized Aerobic–Anaerobic Energy Balance Compensation Theory

We recently reported that the restoration of cervical vertebral arterial blood flow access (measured as systolic peak (PS)) to the rhomboid fossa leads to the recovery of the HbA1c level in the case of patients with a pre-Diabetes Mellitus (pre-DM) condition. The theory of centralized aerobic–anaerobic energy balance compensation (TCAAEBC) provides a successful theoretical explanation for this observation. It considers the human body as a dissipative structure. Reported connections between arterial hypertension (AHT) and the level of HbA1c are linked through OABFRH. According to the TCAAEBC, this delivers incorrect information about blood oxygen availability to the cerebellum. The restoration of PS normalizes AHT in 5–6 weeks and HbA1c in 12–13 weeks. In the current study, we demonstrate the model which fits the obtained experimental data. According to the model, pathways of onset and recovery from pre-DM are different. The consequence of these differences is discussed. The great significance of the TCAAEBC for medical practice forces the creation of an appropriate mathematical model, but the required adjustment of the model needs experimental data which can only be obtained from an animal model(s). The essential part of this study is devoted to the analysis of the advantages and disadvantages of widely available common mammalian models for TCAAEBC cases.

Авторы
Vetcher Alexandre A. 1, 2 , Zhukov Kirill V.1 , Gasparyan Bagrat A.1 , Borovikov Pavel I.3 , Karamian Arfenia S. 2 , Rejepov Dovlet T.2 , Kuznetsova Maria N. 2 , Shishonin Alexander Y.1
Журнал
Издательство
MDPI AG
Номер выпуска
8
Язык
Английский
Страницы
2147
Статус
Опубликовано
Том
11
Год
2023
Организации
  • 1 Complementary and Integrative Health Clinic of Dr. Shishonin, 5 Yasnogorskaya Str., 117588 Moscow, Russia
  • 2 Institute of Biochemical Technology and Nanotechnology, Peoples’ Friendship University of Russia, n.a. P. Lumumba (RUDN), 6 Miklukho-Maklaya St., 117198 Moscow, Russia
  • 3 FSBI National Medical Research Center for Obstetrics, Gynecology and Perinatology n.a. V. I. Kulakov of the Ministry of Healthcare of the Russian Federation, 4, Oparina Str., 117997 Moscow, Russia
Ключевые слова
arterial hypertension; blood pressure; diabetes mellitus; systolic peak; rhomboid fossa; central nervous system
Дата создания
12.09.2023
Дата изменения
12.09.2023
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/94263/
Поделиться

Другие записи

Bekkouche Incherah, Kuznetsova Maria N., Rejepov Dovlet T., Vetcher Alexandre A., Shishonin Alexander Y.
Nanomaterials. MDPI AG. Том 13. 2023. 2449 с.