900 patients with different psychosomatic diseases were observed. A leading mechanism of the pathology development was found to be formation (through the period of psychosomatic reactions) of mono- and polysystemic psychosomatic cycles responsible for the development of both primary and secondary psychosomatoses in context of a single psychosomatic continuum. On the basis of neurotic depression, at first, primary psychosomatosis developed. Besides, quantitative increase of psychosomatic pathology was observed within a damaged system. As far as monosystemic psychosomatic cycle transformed into polysystemic one, secondary psychosomatosis formed including psychosomatic pathology of some other organs and systems.