Tandem Michael addition - Hoffman elimination sequence of DMAD on tetrahydropyrrolo[3,2-C]pyridines. New route to vinylpyrroles.

The reaction of tetrahydropyrrolo [3,2-c]pyridlines with DMAD in THF at room temperature results in piperidine ring cleavage producing alpha- or beta-vinylpyrroles in moderate to good yields. The resulting compounds are hardly available by other synthetic means and are good candidates for further transformations.

Издательство
Freund Publishing House Ltd
Номер выпуска
5
Язык
Английский
Страницы
461-466
Статус
Опубликовано
Том
7
Год
2001
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