Aim. To investigate a new technique of transcutaneous electroneurostimulation of reflexogenic zones by short-impulse current (DiaDENS-Cardio) as a potential method to improve blood pressure (BP) control in patients with arterial hypertension (AH) uncontrolled by three-component therapy. Material and methods. A placebo-controlled study of DiaDENS-Cardio device included 60 AH patients, receiving regular three-component anti hypertensive therapy but failing to achieve the target BP level < 140/90 mm Hg. BP was self-measured (SMBP) and monitored for 24 hours (24-hour BPM). Results. Systolic BP decreased after two days of DiaDENS-Cardio therapy, as demonstrated by SMBP (123,4 5,4 vs. 144,9 +/- 7,4 mm Hg; p<0,05) and 24-hour BPM (125,8 +/- 4,9 vs. 147,1 +/- 11,7 mm Hg; p<0,05). Conclusion. DiaDENS-Cardio therapy significantly improved BP control in patients with resistant AH.