The paper is a continuation of Part I and contains several further results on generalized boundary triples, the corresponding Weyl functions, and applications of this technique to ordinary and partial differential operators. We establish a connection between Post's theory of boundary pairs of closed nonnegative forms on the one hand and the theory of generalized boundary triples of nonnegative symmetric operators on the other hand. Applications to the Laplacian operator on bounded domains with smooth, Lipschitz, and even rough boundary, as well as to mixed boundary value problem for the Laplacian are given. Other applications concern with the momentum, Schrödinger, and Dirac operators with local point interactions. These operators demonstrate natural occurrence of (Formula presented.) -generalized boundary triples with domain invariant Weyl functions and essentially selfadjoint reference operators A0. © 2022 The Authors. Mathematische Nachrichten published by Wiley-VCH GmbH.